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Short- and long-term mortality following hypnotic use
Stockholm University, Faculty of Science, Department of Mathematics.
Stockholm University, Faculty of Social Sciences, Stress Research Institute. Karolinska Institutet, Sweden.ORCID iD: 0000-0001-8049-8504
Number of Authors: 42020 (English)In: Journal of Sleep Research, ISSN 0962-1105, E-ISSN 1365-2869, Vol. 29, no 4, article id e13061Article in journal (Refereed) Published
Abstract [en]

Potential long-term consequences of hypnotics remain controversial. We used the prospective Swedish National March Cohort, a study based on 41,695 participants with a mean follow-up duration of 18.9 years. Logistic regression models and Cox proportional hazards models with attained age as timescale were used to assess associations of hypnotic use with short- and long-term mortality. The proportion of subjects who initiated or discontinued hypnotic use during follow-up was substantial. All groups of hypnotics were associated with increased mortality within 2 years after a first prescription, with an overall OR of 2.38 (95% CI, 2.13-2.66). The association was more pronounced among subjects younger than 60 years (OR, 6.16; 95% CI, 3.98-9.52). There was no association between hypnotic use and long-term mortality. The association between hypnotic use and increased mortality was thus restricted to a relatively short period after treatment initiation, and may be explained in terms of confounding by indication.

Place, publisher, year, edition, pages
2020. Vol. 29, no 4, article id e13061
Keywords [en]
hypnotic use, insomnia, mortality, prospective cohort study
National Category
Neurosciences Psychology
Research subject
Psychology
Identifiers
URN: urn:nbn:se:su:diva-182977DOI: 10.1111/jsr.13061ISI: 000533358000001PubMedID: 32420667OAI: oai:DiVA.org:su-182977DiVA, id: diva2:1452471
Available from: 2020-07-06 Created: 2020-07-06 Last updated: 2022-02-26Bibliographically approved

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Hössjer, OlaÅkerstedt, Torbjorn

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CiteExportLink to record
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