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Electron Beam-Induced Transformation in High-Density Amorphous Ices
Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).ORCID iD: 0000-0002-8271-3906
Stockholm University, Faculty of Science, Department of Physics.
Stockholm University, Faculty of Science, Department of Physics.ORCID iD: 0000-0002-7319-7807
Number of Authors: 42020 (English)In: Journal of Physical Chemistry B, ISSN 1520-6106, E-ISSN 1520-5207, Vol. 124, no 41, p. 9283-9288Article in journal (Refereed) Published
Abstract [en]

Amorphous ice is commonly used as a noncrystalline matrix for protecting sensitive biological samples in cryogenic electron microscopy (cryo-EM). The amorphization process of water is complex, and at least two amorphous states of different densities are known to exist, high- and low-density amorphous ices (HDA and LDA). These forms are considered to be the counterparts of two distinct liquid states, namely, high- and low-density liquid water. Herein, we investigate the HDA to LDA transition using electron diffraction and cryo-EM. The observed phase transition is induced by the impact of electrons, and we discuss two different mechanisms, namely, local heating and beam-induced motion of water molecules. The temperature increase is estimated by comparison with X-ray scattering experiments on identically prepared samples. Our results suggest that HDA, under the conditions used in our cryo-EM measurements, is locally heated above its glass-transition temperature.

Place, publisher, year, edition, pages
2020. Vol. 124, no 41, p. 9283-9288
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Chemical Sciences
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URN: urn:nbn:se:su:diva-188242DOI: 10.1021/acs.jpcb.0c08232ISI: 000582569100033PubMedID: 32997503OAI: oai:DiVA.org:su-188242DiVA, id: diva2:1512898
Available from: 2020-12-28 Created: 2020-12-28 Last updated: 2022-02-25Bibliographically approved

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Xu, HongyiAmann-Winkel, Katrin

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