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Thermoneutrality-Induced Macrophage Accumulation in Brown Adipose Tissue Does Not Impair the Tissue's Competence for Cold-Induced Thermogenic Recruitment
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute. University Medical Center Hamburg-Eppendorf, Germany.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.ORCID iD: 0000-0001-8044-5410
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Number of Authors: 62020 (English)In: Frontiers in Endocrinology, E-ISSN 1664-2392, Vol. 11, article id 568682Article in journal (Refereed) Published
Abstract [en]

Brown adipose tissue from mice living under conditions approaching human thermal and nutritional conditions (prolonged exposure to thermoneutral temperature and to an energy-rich (high-fat, high-sugar) diet) - referred to as physiologically humanized mice, displays morphological and molecular characteristics significantly different from those observed in young, chow-fed mice maintained at room temperature - referred to as standard mice. Here, we further examined brown fat from physiologically humanized and standard mice, as well as from mice exposed to thermoneutrality for a long time but not to an energy-rich diet - referred to here as long-term thermoneutral mice. Global transcriptome analysis of brown fat revealed that genes that were the most upregulated in brown fat of thermoneutral mice (both physiologically humanized and long-term thermoneutral) were those related to inflammatory processes, including genes expressed selectively in macrophages. Cellular and molecular analyses confirmed that brown fat from thermoneutral mice was heavily infiltrated by macrophages, predominantly organized into crown-like structures. However, despite this, the brown fat of thermoneutral mice retained full competence to attain the greatest possible recruitment state and became macrophage-depleted during the process of cold acclimation. Thus, profound macrophage accumulation does not influence the thermogenic recruitment competence of brown fat.

Place, publisher, year, edition, pages
2020. Vol. 11, article id 568682
Keywords [en]
brown fat, thermogenic capacity, UCP1, macrophages, thermoneutrality
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:su:diva-188202DOI: 10.3389/fendo.2020.568682ISI: 000588782900001PubMedID: 33193086OAI: oai:DiVA.org:su-188202DiVA, id: diva2:1513176
Available from: 2020-12-29 Created: 2020-12-29 Last updated: 2024-01-17Bibliographically approved

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Fischer, Alexander W.de Jong, Jasper M. A.Petrovic, Natasa

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