Background: The life transition between late adolescence and emerg- ing adulthood is often troubled, with one in three university students showing symptoms of depression and anxiety. Help-seeking behavior is low due to emotional and practical barriers, generating a treatment gap. The purpose of this project is to map Swedish university stu- dents’ mental health problems and deliver e-health interventions to those at risk, thus reducing the treatment gap. The project is the first in a Swedish partnership with the WHO WMH-ICS 20-country international consortium.

Methods: The project is organized in four work packages (WPs) over four years, beginning in 2020. An annual epidemiological survey targeting first-year students will map mental health problems and disor- ders, including suicidal thoughts and behaviors (WP1), and annual follow-up surveys will track participants’ developmental trajectories in terms of persisting problems and help-seeking behavior (WP2). Students identified as at-risk will be offered participation in a three-arm random- ized controlled trial (RCT), delivering guided or unguided transdiagnostic e-treatment, or treatment as usual in a control group (WP3). At 5-week follow-up, participants at higher risk of failing treatment according to a precision treatment algorithm will be randomized to personally adapted e- treatment or continued WP3 treatment in a secondary trial-within-trial (WP4). WP1 will begin in the spring of 2020 with a pilot survey at selected Swedish universities

Results: We anticipate being able to present preliminary pilot survey results.Conclusions and implications: We envisage high potential for reducing mental health problems among Swedish university students, improving academic performance and reducing dropout.