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Integrative transcriptomic analysis of tissue-specific metabolic crosstalk after myocardial infarction
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics. Stockholm University, Science for Life Laboratory (SciLifeLab).ORCID iD: 0000-0001-7972-0083
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Number of Authors: 132021 (English)In: eLIFE, E-ISSN 2050-084X, Vol. 10, article id e66921Article in journal (Refereed) Published
Abstract [en]

Myocardial infarction (MI) promotes a range of systemic effects, many of which are unknown. Here, we investigated the alterations associated with MI progression in heart and other metabolically active tissues (liver, skeletal muscle, and adipose) in a mouse model of MI (induced by ligating the left ascending coronary artery) and sham-operated mice. We performed a genomewide transcriptomic analysis on tissue samples obtained 6- and 24 hr post MI or sham operation. By generating tissue-specific biological networks, we observed: (1) dysregulation in multiple biological processes (including immune system, mitochondrial dysfunction, fatty-acid beta-oxidation, and RNA and protein processing) across multiple tissues post MI and (2) tissue-specific dysregulation in biological processes in liver and heart post MI. Finally, we validated our findings in two independent MI cohorts. Overall, our integrative analysis highlighted both common and specific biological responses to MI across a range of metabolically active tissues.

Place, publisher, year, edition, pages
2021. Vol. 10, article id e66921
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Biological Sciences
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URN: urn:nbn:se:su:diva-195172DOI: 10.7554/eLife.66921ISI: 000661322200001PubMedID: 33972017OAI: oai:DiVA.org:su-195172DiVA, id: diva2:1584057
Available from: 2021-08-10 Created: 2021-08-10 Last updated: 2022-02-25Bibliographically approved

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Benfeitas, RuiZhang, Cheng

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