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Antagonising Chromatin Remodelling Activities in the Regulation of Mammalian Ribosomal Transcription
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.ORCID iD: 0000-0003-4810-2076
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.ORCID iD: 0000-0001-9225-3264
Number of Authors: 22021 (English)In: Genes, ISSN 2073-4425, E-ISSN 2073-4425, Vol. 12, no 7, article id 961Article, review/survey (Refereed) Published
Abstract [en]

Ribosomal transcription constitutes the major energy consuming process in cells and is regulated in response to proliferation, differentiation and metabolic conditions by several signalling pathways. These act on the transcription machinery but also on chromatin factors and ncRNA. The many ribosomal gene repeats are organised in a number of different chromatin states; active, poised, pseudosilent and repressed gene repeats. Some of these chromatin states are unique to the 47rRNA gene repeat and do not occur at other locations in the genome, such as the active state organised with the HMG protein UBF whereas other chromatin state are nucleosomal, harbouring both active and inactive histone marks. The number of repeats in a certain state varies on developmental stage and cell type; embryonic cells have more rRNA gene repeats organised in an open chromatin state, which is replaced by heterochromatin during differentiation, establishing different states depending on cell type. The 47S rRNA gene transcription is regulated in different ways depending on stimulus and chromatin state of individual gene repeats. This review will discuss the present knowledge about factors involved, such as chromatin remodelling factors NuRD, NoRC, CSB, B-WICH, histone modifying enzymes and histone chaperones, in altering gene expression and switching chromatin states in proliferation, differentiation, metabolic changes and stress responses.

Place, publisher, year, edition, pages
2021. Vol. 12, no 7, article id 961
Keywords [en]
rRNA gene repeats, chromatin states, NuRD, B-WICH, NoRC, histone modifications, non-coding RNA
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-197360DOI: 10.3390/genes12070961ISI: 000676577200001PubMedID: 34202617OAI: oai:DiVA.org:su-197360DiVA, id: diva2:1599127
Available from: 2021-09-30 Created: 2021-09-30 Last updated: 2022-02-25Bibliographically approved

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Tariq, KanwalÖstlund Farrants, Ann-Kristin

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