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Journey to the Center of the Cell: Cytoplasmic and Nuclear Actin in Immune Cell Functions
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute. New York University Abu Dhabi (NYUAD), United Arab Emirates.ORCID iD: 0000-0002-9546-7425
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Number of Authors: 52021 (English)In: Frontiers in Cell and Developmental Biology, E-ISSN 2296-634X, Vol. 9, article id 682294Article, review/survey (Refereed) Published
Abstract [en]

Actin cytoskeletal dynamics drive cellular shape changes, linking numerous cell functions to physiological and pathological cues. Mutations in actin regulators that are differentially expressed or enriched in immune cells cause severe human diseases known as primary immunodeficiencies underscoring the importance of efficienct actin remodeling in immune cell homeostasis. Here we discuss recent findings on how immune cells sense the mechanical properties of their environement. Moreover, while the organization and biochemical regulation of cytoplasmic actin have been extensively studied, nuclear actin reorganization is a rapidly emerging field that has only begun to be explored in immune cells. Based on the critical and multifaceted contributions of cytoplasmic actin in immune cell functionality, nuclear actin regulation is anticipated to have a large impact on our understanding of immune cell development and functionality.

Place, publisher, year, edition, pages
2021. Vol. 9, article id 682294
Keywords [en]
immune cells, actin, nucleus, mechanosensing, cytoplasm
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-197431DOI: 10.3389/fcell.2021.682294ISI: 000687589600001PubMedID: 34422807OAI: oai:DiVA.org:su-197431DiVA, id: diva2:1599958
Available from: 2021-10-03 Created: 2021-10-03 Last updated: 2022-03-10Bibliographically approved

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Percipalle, Piergiorgio

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