Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Stress-induced FGF21 and GDF15 in obesity and obesity resistance
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.ORCID iD: 0000-0002-6618-7379
Number of Authors: 22021 (English)In: Trends in endocrinology and metabolism, ISSN 1043-2760, E-ISSN 1879-3061, Vol. 32, no 11, p. 904-915Article, review/survey (Refereed) Published
Abstract [en]

Fibroblast growth factor 21 (FGF21) and growth differentiation factor 15 (GDF15) are established as stress-responsive cytokines that can modulate energy balance by increasing energy expenditure or suppressing food intake, respectively. Despite their pharmacologically induced beneficial effects on obesity and comorbidities, circulating levels of both cytokines are elevated during obesity and related metabolic complications. On the other hand, endocrine crosstalk via FGF21 and GDF15 was also reported to play a crucial role in genetically modified mouse models of mitochondrial perturbations leading to diet-induced obesity (DIO) resistance. This review aims to dissect the complexities of endogenous FGF21 and GDF15 action in obesity versus DIO resistance for the regulation of energy balance in metabolic health and disease.

Place, publisher, year, edition, pages
2021. Vol. 32, no 11, p. 904-915
Keywords [en]
energy balance, mitochondrial integrated stress response, obesity resistance, FGF21, GDF15, muscle, adipose tissue
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:su:diva-198639DOI: 10.1016/j.tem.2021.08.008ISI: 000707636500007PubMedID: 34526227OAI: oai:DiVA.org:su-198639DiVA, id: diva2:1611250
Available from: 2021-11-13 Created: 2021-11-13 Last updated: 2021-11-15Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records

Keipert, Susanne

Search in DiVA

By author/editor
Keipert, Susanne
By organisation
Department of Molecular Biosciences, The Wenner-Gren Institute
In the same journal
Trends in endocrinology and metabolism
Endocrinology and Diabetes

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 40 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf