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Metals in ALS TDP-43 Pathology
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics. Tallinn University of Technology, Estonia.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.ORCID iD: 0000-0001-6836-5610
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Number of Authors: 52021 (English)In: International Journal of Molecular Sciences, ISSN 1661-6596, E-ISSN 1422-0067, Vol. 22, no 22, article id 12193Article, review/survey (Refereed) Published
Abstract [en]

Amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease and similar neurodegenerative disorders take their toll on patients, caregivers and society. A common denominator for these disorders is the accumulation of aggregated proteins in nerve cells, yet the triggers for these aggregation processes are currently unknown. In ALS, protein aggregation has been described for the SOD1, C9orf72, FUS and TDP-43 proteins. The latter is a nuclear protein normally binding to both DNA and RNA, contributing to gene expression and mRNA life cycle regulation. TDP-43 seems to have a specific role in ALS pathogenesis, and ubiquitinated and hyperphosphorylated cytoplasmic inclusions of aggregated TDP-43 are present in nerve cells in almost all sporadic ALS cases. ALS pathology appears to include metal imbalances, and environmental metal exposure is a known risk factor in ALS. However, studies on metal-to-TDP-43 interactions are scarce, even though this protein seems to have the capacity to bind to metals. This review discusses the possible role of metals in TDP-43 aggregation, with respect to ALS pathology.

Place, publisher, year, edition, pages
2021. Vol. 22, no 22, article id 12193
Keywords [en]
neurodegeneration, proteinopathy, metallopathy, protein aggregation, amyloid, metal exposure, metal-protein binding
National Category
Biological Sciences Neurosciences
Identifiers
URN: urn:nbn:se:su:diva-199535DOI: 10.3390/ijms222212193ISI: 000724356100001PubMedID: 34830074OAI: oai:DiVA.org:su-199535DiVA, id: diva2:1620139
Available from: 2021-12-15 Created: 2021-12-15 Last updated: 2022-02-25Bibliographically approved

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Berntsson, ElinaWärmländer, Sebastian K. T. S.Roos, Per M.

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