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Engineered mesoporous silica reduces long-term blood glucose and HbA1c, and improves metabolic parameters in prediabetics
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Number of Authors: 112022 (English)In: Nanomedicine, ISSN 1743-5889, E-ISSN 1748-6963, Vol. 17, no 1, p. 9-22Article in journal (Refereed) Published
Abstract [en]

Aim: To investigate the effect of oral consumption of engineered mesoporous silica particles, SiPore15®, on long-term blood glucose levels and other metabolic parameters in individuals with prediabetes and newly diagnosed Type 2 diabetes. Method: An open-label, single-arm, multicenter trial was conducted in which SiPore15 was consumed three times daily for 12 weeks. Hemoglobin A1c (HbA1c, primary end point) and an array of metabolic parameters were measured at baseline and throughout the trial. Result: SiPore15 treatment significantly reduced HbA1c by a clinically meaningful degree and improved several disease-associated parameters with minimal side effects. Conclusion: The results from this study demonstrate the potential use of SiPore15 as a treatment for prediabetes that may also delay or prevent the onset of Type 2 diabetes.

Place, publisher, year, edition, pages
2022. Vol. 17, no 1, p. 9-22
Keywords [en]
diabetes prevention, HbA1c, medical device, mesoporous silica particles, prediabetes, Type 2 diabetes
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:su:diva-201430DOI: 10.2217/nnm-2021-0235ISI: 000725078400001OAI: oai:DiVA.org:su-201430DiVA, id: diva2:1633965
Available from: 2022-02-01 Created: 2022-02-01 Last updated: 2022-02-01Bibliographically approved

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Iqbal, Muhammad NaeemBengtsson, Tore

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Iqbal, Muhammad NaeemBengtsson, Tore
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Department of Materials and Environmental Chemistry (MMK)Department of Molecular Biosciences, The Wenner-Gren Institute
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Nanomedicine
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