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SARS-CoV-2-specific B- and T-cell immunity in a population-based study of young Swedish adults
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Number of Authors: 172022 (English)In: Journal of Allergy and Clinical Immunology, ISSN 0091-6749, E-ISSN 1097-6825, Vol. 149, no 1, p. 65-75Article in journal (Refereed) Published
Abstract [en]

Background: Young adults are now considered major spreaders of coronavirus disease 2019 (COVID-19) disease. Although most young individuals experience mild to moderate disease, there are concerns of long-term adverse health effects. The impact of COVID-19 disease and to which extent population-level immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exists in young adults remain unclear.

Objective: We conducted a population-based study on humoral and cellular immunity to SARS-CoV-2 and explored COVID-19 disease characteristics in young adults.

Methods: We invited participants from the Swedish BAMSE (Barn [Children], Allergy Milieu, Stockholm, Epidemiology) birth cohort (age 24-27 years) to take part in a COVID-19 followup. From 980 participants (October 2020 to June 2021), we here present data on SARS-CoV-2 receptor-binding domain-specific IgM, IgA, and IgG titers measured by ELISA and on symptoms and epidemiologic factors associated with seropositivity. Further, SARS-CoV-2-specific memory B-and T-cell responses were detected for a subpopulation (n 5 108) by ELISpot and FluoroSpot.

Results: A total of 28.4% of subjects were seropositive, of whom 18.4% were IgM single positive. One in 7 seropositive subjects was asymptomatic. Seropositivity was associated with use of public transport, but not with sex, asthma, rhinitis, IgE sensitization, smoking, or body mass index. In a subset of representative samples, 20.7% and 35.0% had detectable SARSCoV-2 specific B-and T-cell responses, respectively. B-and T-cell memory responses were clearly associated with seropositivity, but T-cell responses were also detected in 17.2% of seronegative subjects.

Conclusions: Assessment of IgM and T-cell responses may improve population-based estimations of SARS-CoV-2 infection. The pronounced surge of both symptomatic and asymptomatic infections among young adults indicates that the large-scale vaccination campaign should be continued. (J Allergy Clin Immunol 2022;149:65-75.)

Place, publisher, year, edition, pages
2022. Vol. 149, no 1, p. 65-75
Keywords [en]
SARS-CoV-2, COVID-19 disease, IgM, IgA, IgG, mem-ory T cells, memory B cells, young adults, population-based cohort, asthma, risk factors
National Category
Infectious Medicine Immunology in the medical area
Identifiers
URN: urn:nbn:se:su:diva-201949DOI: 10.1016/j.jaci.2021.10.014ISI: 000744544500014PubMedID: 34695490OAI: oai:DiVA.org:su-201949DiVA, id: diva2:1636273
Available from: 2022-02-09 Created: 2022-02-09 Last updated: 2022-10-25Bibliographically approved

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Björkander, SophiaSherina, NataliaAndréll, Juni

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Science for Life Laboratory (SciLifeLab)Department of Biochemistry and Biophysics
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