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Impact of endocrine disrupting chemicals on neurodevelopment: the need for better testing strategies for endocrine disruption-induced developmental neurotoxicity
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.ORCID iD: 0000-0002-4886-9042
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
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Number of Authors: 62022 (English)In: Expert Review of Endocrinology & Metabolism, ISSN 1744-6651, Vol. 17, no 2, p. 131-141Article in journal (Refereed) Published
Abstract [en]

Introduction: Brain development is highly dependent on hormonal regulation. Exposure to chemicals disrupting endocrine signaling has been associated with neurodevelopmental impairment. This raises concern about exposure to the suspected thousands of endocrine disruptors, and has resulted in efforts to improve regulation of these chemicals. Yet, the causal links between endocrine disruption and developmental neurotoxicity, which would be required for regulatory action, are still largely missing.

Areas covered: In this review, we illustrate the importance of two endocrine systems, thyroid hormone and retinoic acid pathways, for neurodevelopment. We place special emphasis on TH and RA synthesis, metabolism, and how endocrine disrupting chemicals known or suspected to affect these systems are associated with developmental neurotoxicity.

Expert opinion: While it is clear that neurodevelopment is dependent on proper hormonal functioning, and evidence is increasing for developmental neurotoxicity induced by endocrine disrupting chemicals, this is not grasped by current chemical testing. Thus, there is an urgent need to develop test methods detecting endocrine disruption in the context of neurodevelopment. Key to this development is further mechanistic insights on the involvement of endocrine signaling in neurodevelopment as well as increased support to develop and validate new test methods for the regulatory context.

Place, publisher, year, edition, pages
2022. Vol. 17, no 2, p. 131-141
Keywords [en]
Developmental neurotoxicity, endocrine disrupting chemicals, neurodevelopment, retinoic acid, thyroid hormone
National Category
Pharmacology and Toxicology Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:su:diva-203509DOI: 10.1080/17446651.2022.2044788ISI: 000766099100001PubMedID: 35255767Scopus ID: 2-s2.0-85126198442OAI: oai:DiVA.org:su-203509DiVA, id: diva2:1649291
Available from: 2022-04-04 Created: 2022-04-04 Last updated: 2022-06-08Bibliographically approved

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Johansson, YlvaHinojosa, Maria

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