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Diet-Induced Thermogenesis: Principles and Pitfalls
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.ORCID iD: 0000-0003-2070-1587
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.ORCID iD: 0000-0001-6594-2363
2022 (English)In: Brown Adipose Tissue: Methods and Protocols / [ed] David A. Guertin, Christian Wolfrum, New York: Humana Press, 2022, p. 177-202Chapter in book (Refereed)
Abstract [en]

Concerning diet-induced thermogenesis, methodological issues relate mainly to the interpretation of measurements, rather than to the technical methodology as such. In the following, we point to a series of issues where the analysis often suggests the occurrence of UCP1-related diet-induced thermogenesis but where the observations are often the consequences of a process that has induced leanness rather than being the cause of them. We particularly emphasize the necessity of focusing on the total organism when interpreting biochemical and molecular data, where the concept of total tissue values rather than relative data better reflects physiologically important alterations. We stress the importance of performing experiments at thermoneutrality in order to obtain clinically relevant data and stress that true thermogenic agents may be overlooked if this is not done. 

Place, publisher, year, edition, pages
New York: Humana Press, 2022. p. 177-202
Series
Methods in Molecular Biology, ISSN 1064-3745, E-ISSN 1940-6029
Keywords [en]
UCP1, Thermogenesis, Diet-induced thermogenesis, Metabolic efficiency
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-204948DOI: 10.1007/978-1-0716-2087-8_12PubMedID: 35167098Scopus ID: 2-s2.0-85124636688ISBN: 978-1-0716-2086-1 (print)ISBN: 978-1-0716-2087-8 (electronic)OAI: oai:DiVA.org:su-204948DiVA, id: diva2:1660130
Available from: 2022-05-23 Created: 2022-05-23 Last updated: 2022-05-23Bibliographically approved

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Nedergaard, JanCannon, Barbara

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