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Mono-N-Alkylation of Sulfonamides with Alcohols Catalyzed by Iridium N-Heterocyclic Carbene-Phosphine Complexes
Stockholm University, Faculty of Science, Department of Organic Chemistry.ORCID iD: 0000-0001-7788-3866
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Number of Authors: 72022 (English)In: Asian Journal of Organic Chemistry, ISSN 2193-5807, Vol. 11, no 7, article id e202200178Article in journal (Refereed) Published
Abstract [en]

A N-heterocyclic carbene-phosphine iridium complex is presented for the efficient and selective mono-N-alkylation of sulfonamides with alcohols based on a borrowing hydrogenation strategy. Herein, water is the only by-product and this methodology thus offers a more environmentally benign and interesting alternative to the use of traditional alkylating reagents. This facile protocol tolerates a large number of (hetero) aromatic and aliphatic sulfonamides as well as (hetero) aromatic and aliphatic alcohols to obtain the desired product is high isolated yield (up to 98%). The alkylation completely retards after the formation of the secondary sulfonamide and no over-alkylation was observed in all cases. The option to run the reaction under solvent-free conditions as well as the scalability of this borrowing hydrogenation are key features of this protocol.

Place, publisher, year, edition, pages
2022. Vol. 11, no 7, article id e202200178
Keywords [en]
Alcohols, Borrowing hydrogenation, Iridium catalysis, N-alkylation, Sulfonamides
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:su:diva-207047DOI: 10.1002/ajoc.202200178ISI: 000813631800001Scopus ID: 2-s2.0-85132147801OAI: oai:DiVA.org:su-207047DiVA, id: diva2:1681078
Available from: 2022-07-05 Created: 2022-07-05 Last updated: 2022-08-05Bibliographically approved

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Peters, Bram B. C.Yang, JianpingAndersson, Pher G.

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