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Approaching Protein Aggregation and Structural Dynamics by Equilibrium and Nonequilibrium Paramagnetic Perturbation
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Number of Authors: 62022 (English)In: Analytical Chemistry, ISSN 0003-2700, E-ISSN 1520-6882, Vol. 94, no 31, p. 10949-10958Article in journal (Refereed) Published
Abstract [en]

PENELOP (Paramagnetic Equilibrium vs Nonequilibrium magnetization Enhancement or LOss Perturbation) is the presented nuclear magnetic resonance (NMR) approach to identify at once the location of proteins' exposed surface, hindered accessibility, and exchange processes occurring on a mu s-ms time scale. In addition to mapping the protein surface accessibility, the application of this method under specific conditions makes it possible to distinguish conformational mobility and chemical exchange processes, thereby providing an alternative to characterization by more demanding techniques (transverse relaxation dispersion, saturation transfer, and high-pressure NMR). Moreover, its high sensitivity enables studying samples at low, physiologically more relevant concentrations. Association, dynamics, and oligomerization are addressed by PENELOP for a component of SARS-CoV-2 replication transcription complex and an amyloidogenic protein.

Place, publisher, year, edition, pages
2022. Vol. 94, no 31, p. 10949-10958
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Chemical Sciences
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URN: urn:nbn:se:su:diva-208297DOI: 10.1021/acs.analchem.2c00751ISI: 000834107200001PubMedID: 35877130Scopus ID: 2-s2.0-85135894637OAI: oai:DiVA.org:su-208297DiVA, id: diva2:1691045
Available from: 2022-08-29 Created: 2022-08-29 Last updated: 2022-08-29Bibliographically approved

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Percipalle, Piergiorgio

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Department of Molecular Biosciences, The Wenner-Gren Institute
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