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Staphylococcus aureus-derived factors promote human Th9 cell polarization and enhance a transcriptional program associated with allergic inflammation
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.ORCID iD: 0000-0001-6619-6884
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute. University of Groningen, Netherlands.ORCID iD: 0000-0001-8525-9895
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
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Number of Authors: 72023 (English)In: European Journal of Immunology, ISSN 0014-2980, E-ISSN 1521-4141, Vol. 53, no 3, article id 2250083Article in journal (Refereed) Published
Abstract [en]

T helper (Th) 9 cells, characterized by robust secretion of IL-9, have been increasingly associated with allergic diseases. However, whether and how Th9 cells are modulated by environmental stimuli remains poorly understood. In this study, we show that in vitro exposure of human PBMCs or isolated CD4 T-cells to Staphylococcus (S.) aureus-derived factors, including its toxins, potently enhances Th9 cell frequency and IL-9 secretion. Furthermore, as revealed by RNA sequencing analysis, S. aureus increases the expression of Th9-promoting factors at the transcriptional level, such as FOXO1, miR-155, and TNFRSF4. The addition of retinoic acid (RA) dampens the Th9 responses promoted by S. aureus and substantially changes the transcriptional program induced by this bacterium, while also altering the expression of genes associated with allergic inflammation. Together, our results demonstrate a strong influence of microbial and dietary factors on Th9 cell polarization, which may be important in the context of allergy development and treatment.

Place, publisher, year, edition, pages
2023. Vol. 53, no 3, article id 2250083
Keywords [en]
allergy, environmental stimuli, retinoic acid, Staphylococcus aureus, T helper 9 cells
National Category
Immunology in the medical area Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:su:diva-215303DOI: 10.1002/eji.202250083ISI: 000914727500001PubMedID: 36550071Scopus ID: 2-s2.0-85146465220OAI: oai:DiVA.org:su-215303DiVA, id: diva2:1741622
Available from: 2023-03-06 Created: 2023-03-06 Last updated: 2023-04-25Bibliographically approved

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Badolati, Isabellavan Der Heiden, MariekeZuurveld, MaritBjörkander, SophiaSverremark-Ekström, Eva

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Badolati, Isabellavan Der Heiden, MariekeZuurveld, MaritBjörkander, SophiaSverremark-Ekström, Eva
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Department of Molecular Biosciences, The Wenner-Gren Institute
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European Journal of Immunology
Immunology in the medical areaRespiratory Medicine and Allergy

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