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A PERKy way to make mitochondrial cristae
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.ORCID iD: 0000-0001-6594-2363
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.ORCID iD: 0000-0003-2070-1587
2021 (English)In: Trends in endocrinology and metabolism, ISSN 1043-2760, E-ISSN 1879-3061, Vol. 32, no 7, p. 417-419Article, review/survey (Refereed) Published
Abstract [en]

PERK protein, that is canonically associated with the response to endoplasmic reticulum stress, may be acquiring a new role as a regulator of the growth of mitochondrial cristae. This role is pertinent not only to the recruitment of brown adipose tissue thermogenic capacity but probably also to directing cristae formation in highly metabolically active organs such as the heart.

Place, publisher, year, edition, pages
2021. Vol. 32, no 7, p. 417-419
Keywords [en]
brown adipose tissue, cristae, endoplasmic reticulum stress, MICOS, mitochondria, norepinephrine
National Category
Endocrinology and Diabetes Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:su:diva-216147DOI: 10.1016/j.tem.2021.04.003ISI: 000659494900002PubMedID: 33952415Scopus ID: 2-s2.0-85105358081OAI: oai:DiVA.org:su-216147DiVA, id: diva2:1748991
Available from: 2023-04-05 Created: 2023-04-05 Last updated: 2023-04-05Bibliographically approved

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Cannon, BarbaraNedergaard, Jan

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