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Interactive association between insomnia symptoms and sleep duration for the risk of dementia: a prospective study in the Swedish National March Cohort
Stockholm University, Faculty of Social Sciences, Department of Psychology, Stress Research Institute. Stockholm University, Faculty of Social Sciences, Department of Psychology, Biological psychology. Karolinska Institutet, Sweden.ORCID iD: 0000-0001-8049-8504
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Number of Authors: 92023 (English)In: Age and Ageing, ISSN 0002-0729, E-ISSN 1468-2834, Vol. 52, no 9, article id afad163Article in journal (Refereed) Published
Abstract [en]

Objective: Given the importance of sleep in maintaining neurocognitive health, both sleep duration and quality might be component causes of dementia. However, the possible role of insomnia symptoms as risk factors for dementia remain uncertain. Methods: We prospectively studied 22,078 participants in the Swedish National March Cohort who were free from dementia and stroke at baseline. Occurrence of dementia was documented by national registers during a median follow-up period of 19.2 years. Insomnia symptoms and sleep duration were ascertained by Karolinska Sleep Questionnaire. Multivariable Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI). Results: Compared to participants without insomnia at baseline, those who reported any insomnia symptom experienced a greater incidence of dementia during follow-up (HR 1.08, 95% CI: 1.03, 1.35). Difficulty initiating sleep versus non insomnia (HR 1.24, 95% CI: 1.02, 1.52), but not difficulty maintaining sleep or early morning awakening was associated with an increased risk of dementia. Short sleep duration was associated with increased risk of dementia (6 h vs. 8 h, HR 1.29, 95% CI: 1.11-1.51; 5 h vs. 8 h, HR 1.26, 95% CI: 1.00-1.57). Stratified analyses suggested that insomnia symptoms increased the risk of dementia only amongst participants with =7 h sleep (vs. non-insomnia HR 1.24, 95% CI: 1.00-1.54, P=0.05), but not amongst short sleepers (<7 h). Short sleep duration also did not further inflate the risk of dementia amongst insomniacs. Conclusion: Insomnia and short sleep duration increase the risk of dementia amongst middle-aged to older adults.

Place, publisher, year, edition, pages
Oxford University Press, 2023. Vol. 52, no 9, article id afad163
Keywords [en]
insomnia, sleep duration, dementia, national cohort, longitudinal study, older people
National Category
Neurosciences
Research subject
Psychology
Identifiers
URN: urn:nbn:se:su:diva-222235DOI: 10.1093/ageing/afad163ISI: 001063482100001PubMedID: 37676841Scopus ID: 2-s2.0-85173064876OAI: oai:DiVA.org:su-222235DiVA, id: diva2:1804166
Note

This research was supported by ZJU 100 Young Professor Project (X.T.), Åke Wiberg Foundation (X.T., M19–0266), Fredrik and Ingrid Thuring Foundation (X.T., 2019–00488) and Region Stockholm Clinical Research Appointment (Y.T.L.), the Swedish Research Council (HX.W., 2018–02998), and the Swedish Research Council for Health, Working life, and Welfare (HX.W., 2019–01120, 2020–00313).

Available from: 2023-10-11 Created: 2023-10-11 Last updated: 2024-01-30Bibliographically approved

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Åkerstedt, TorbjörnPei, Jin-JingWang, Hui-Xin

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Tan, XiaoÅkerstedt, TorbjörnLagerros, Ylva TrollePei, Jin-JingWang, Hui-Xin
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