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Highly recruited brown adipose tissue does not in itself protect against obesity
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute. Institute of Physiology of the Czech Academy of Sciences, Czech Republic.ORCID iD: 0000-0002-1111-9109
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2023 (English)In: Molecular Metabolism, ISSN 2212-8778, Vol. 76, article id 101782Article in journal (Refereed) Published
Abstract [en]

Objective: The possibility to counteract the development of obesity in humans by recruiting brown or brite/beige adipose tissue (and thus UCP1) has attracted much attention. Here we examine if a diet that can activate diet-induced thermogenesis can exploit pre-enhanced amounts of UCP1 to counteract the development of diet-induced obesity.Methods: To investigate the anti-obesity significance of highly augmented amounts of UCP1 for control of body energy reserves, we physiologically increased total UCP1 amounts by recruitment of brown and brite/beige tissues in mice. We then examined the influence of the augmented UCP1 levels on metabolic parameters when the mice were exposed to a high-fat/high-sucrose diet under thermoneutral conditions.Results: The total UCP1 levels achieved were about 50-fold higher in recruited than in non-recruited mice. Contrary to underlying expectations, in the mice with highly recruited UCP1 and exposed to a high-fat/high-sucrose diet the thermogenic capacity of this UCP1 was completely inactivate. The mice even transiently (in an adipostat-like manner) demonstrated a higher metabolic efficiency and fat gain than did non-recruited mice. This was accomplished without altering energy expenditure or food absorption efficiency. The metabolic efficiency here was indistinguishable from that of mice totally devoid of UCP1.Conclusions: Although UCP1 protein may be available, it is not inevitably utilized for diet-induced thermogenesis. Thus, although attempts to recruit UCP1 in humans may become successful as such, it is only if constant activation of the UCP1 is also achieved that amelioration of obesity development could be attained.& COPY; 2023 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Place, publisher, year, edition, pages
2023. Vol. 76, article id 101782
Keywords [en]
Diet-induced thermogenesis, UCP1, Body weight regulation, Beige adipose tissue, Adipostat, Glucose homeostasis
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:su:diva-222230DOI: 10.1016/j.molmet.2023.101782ISI: 001063640000001PubMedID: 37499977Scopus ID: 2-s2.0-85167813527OAI: oai:DiVA.org:su-222230DiVA, id: diva2:1804188
Available from: 2023-10-11 Created: 2023-10-11 Last updated: 2023-10-11Bibliographically approved

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von Essen, GabriellaLindsund, ErikMaldonado, ElainaZouhar, PetrCannon, BarbaraNedergaard, Jan

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