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Evidence for absence of links between striatal dopamine synthesis capacity and working memory capacity, spontaneous eye-blink rate, and trait impulsivity
Stockholm University, Faculty of Social Sciences, Department of Psychology, Biological psychology.ORCID iD: 0000-0002-1130-0557
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2023 (English)In: eLIFE, E-ISSN 2050-084X, Vol. 12, article id e83161Article in journal (Refereed) Published
Abstract [en]

Individual differences in striatal dopamine synthesis capacity have been associated with working memory capacity, trait impulsivity, and spontaneous eye-blink rate (sEBR), as measured with readily available and easily administered, ‘off-the-shelf’ tests. Such findings have raised the suggestion that individual variation in dopamine synthesis capacity, estimated with expensive and invasive brain positron emission tomography (PET) scans, can be approximated with simple, more pragmatic tests. However, direct evidence for the relationship between these simple trait measures and striatal dopamine synthesis capacity has been limited and inconclusive. We measured striatal dopamine synthesis capacity using [18F]-FDOPA PET in a large sample of healthy volunteers (N = 94) and assessed the correlation with simple, short tests of working memory capacity, trait impulsivity, and sEBR. We additionally explored the relationship with an index of subjective reward sensitivity. None of these trait measures correlated significantly with striatal dopamine synthesis capacity, nor did they have out-of-sample predictive power. Bayes factor analyses indicated the evidence was in favour of absence of correlations for all but subjective reward sensitivity. These results warrant caution for using these off-the-shelf trait measures as proxies of striatal dopamine synthesis capacity.

Place, publisher, year, edition, pages
eLife Sciences Publications Ltd, 2023. Vol. 12, article id e83161
Keywords [en]
striatal dopamine synthesis capacity, working memory capacity, spontaneous eye-blink rate, trait impulsivity
National Category
Psychology (excluding Applied Psychology)
Research subject
Psychology
Identifiers
URN: urn:nbn:se:su:diva-224221DOI: 10.7554/elife.83161ISI: 001007195600001PubMedID: 37083626Scopus ID: 2-s2.0-85157973576OAI: oai:DiVA.org:su-224221DiVA, id: diva2:1817148
Funder
EU, Horizon 2020, 945539Available from: 2023-12-05 Created: 2023-12-05 Last updated: 2024-01-30Bibliographically approved

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Määttä, Jessica I.

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