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Role of cysteine 341 and arginine 348 of GLP-1 receptor in G-protein coupling
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för neurokemi.
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för neurokemi.ORCID-id: 0000-0001-6107-0844
2007 (engelsk)Inngår i: Molecular Biology Reports, ISSN 0301-4851, E-ISSN 1573-4978, Vol. 34, nr 1, s. 53-60Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

We have demonstrated the ability of peptides derived from the third intracellular loop of GLP-1 receptor to differently modulate activity of four different types of G-proteins overexpressed in sf9 cells. In this respect, the involvement of Cys341 in inhibition of Gs and Cys341 in activation of Gs and in inhibition of Gi1, Go, and G11, respectively, indicates their potential role in discrimination between different types of G-proteins. Moreover, these two amino acids from the third intracellular loop might represent an important novel targets for covalent modification by downstream regulators in signaling through GLP-1 receptor.

sted, utgiver, år, opplag, sider
2007. Vol. 34, nr 1, s. 53-60
Emneord [en]
G-protein-coupled receptors, GLP-1, glucagon-like peptide-1 receptor, G proteins, immunoblotting, Sf9 cells
HSV kategori
Identifikatorer
URN: urn:nbn:se:su:diva-20852DOI: 10.1007/s11033-006-9015-9ISI: 000244068100008PubMedID: 17103235OAI: oai:DiVA.org:su-20852DiVA, id: diva2:187378
Tilgjengelig fra: 2008-11-19 Laget: 2008-11-19 Sist oppdatert: 2017-12-13bibliografisk kontrollert

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