An increasing number of studies support the existence of a liquid–liquid critical point (LLCP) in water, implying that under ambient conditions, water is a supercritical mixture of low-density (LDL) and high-density liquid (HDL) structures. Here, we analyse X-ray scattering data in terms of this model. Small-angle X-ray scattering data shows that anomalies are seen at temperatures as high as 360 K. By assuming the local structure in LDL-domains resembles that of the corresponding amorphous solid, we estimate the population of LDL-domains at different temperatures from pair-correlation functions (PCFs). By subtracting the LDL contribution, we isolate the PCF of the HDL component. The temperature-dependent HDL-PCFs show a feature around 4 Å in the supercooled regime, interpreted as interstitials resulting from collapse of the second coordination shell. We define the first coordination shell as neighbours up to 3.3 Å, based on an isosbestic point in the running coordination number. Our analysis shows that the HDL-domains have on average two strongly and two weakly H-bonded neighbours. The LDL population in TIP4P/2005-water is less temperature dependent than in real water, and the HDL component contains more structures with three strongly H-bonded neighbours, leading to a slight overestimation of the first peak of the PCF.