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Characterisation of bioactive cell penetrating peptides from human Cytochrome c: protein mimicry and the development of a novel apoptogenic agent
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för neurokemi.
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för neurokemi. University of Tartu, Estonia.ORCID-id: 0000-0001-6107-0844
Vise andre og tillknytning
2010 (engelsk)Inngår i: Chemistry and Biology, ISSN 1074-5521, E-ISSN 1879-1301, Vol. 17, nr 7, s. 735-744Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Cell penetrating peptides (CPPs) with intrinsic biological activities offer a novel strategy for the modulation of intracellular events. QSAR analysis identified CPPs within human cytochrome c. Two such sequences, Cyt c77–101 and Cyt c86–101, induced tumor cell apoptosis, thus mimicking the role of Cyt c as a key regulator of programmed cell death. Quantitative analyses confirmed that Cyt c77–101 is an extremely efficient CPP. Thus, Cyt c77–101 was selected for modification to incorporate target-specific peptidyl motifs. Chimeric N-terminal extension with a target mimetic of FG nucleoporins significantly enhanced the apoptogenic potency of Cyt c77–101 to a concentration readily achievable in vivo. Moreover, this construct, Nup153-Cyt c, facilitates the dramatic redistribution of nuclear pore complex proteins and thus propounds the nuclear pore complex as a novel target for the therapeutic induction of apoptosis.

sted, utgiver, år, opplag, sider
2010. Vol. 17, nr 7, s. 735-744
HSV kategori
Identifikatorer
URN: urn:nbn:se:su:diva-43389DOI: 10.1016/j.chembiol.2010.05.018ISI: 000280831100010OAI: oai:DiVA.org:su-43389DiVA, id: diva2:356173
Tilgjengelig fra: 2010-10-11 Laget: 2010-10-11 Sist oppdatert: 2017-12-12bibliografisk kontrollert

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