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M1154 – A novel galanin ligand to delineate the galaninergic system
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för neurokemi.
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för neurokemi.
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för neurokemi. University of Tartu, Estonia.ORCID-id: 0000-0001-6107-0844
2010 (engelsk)Inngår i: Peptides 2010: Proceedings of the European Peptide Symposium / [ed] Michal Lebl, Morten Meldal, Knud J. Jensen, Thomas Høeg-Jensen, European Peptide Society and PSP , 2010Konferansepaper, Poster (with or without abstract) (Annet vitenskapelig)
Abstract [en]

The galanin family currently consists of four members, namely galanin, galanin-message-associated peptide (GMAP), galanin-like peptide (GALP) and alarin. The galanin peptide family and its three receptors (GalR1-3) have with compelling evidence been implicated in a variety of human disorders. The co-localization with other neuromodulators and the distinct up-regulation during and after pathological disturbances has drawn attention to this neuropeptide family. Here we present data on receptor binding and preliminary data in functional response for the novel M1154 peptide, including a comparison with several GalR2 selective peptides. M1154 retains high affinity binding to GalR1 and GalR2 although it has no detectable binding to GalR3. We believe that utilizing this selective galanin ligand together with previous published M1145 raise the possibility to delineate the galanin system.

 

sted, utgiver, år, opplag, sider
European Peptide Society and PSP , 2010.
Emneord [en]
Galanin, Neuropeptide, GPCR, receptor ligand, M1154
HSV kategori
Forskningsprogram
neurokemi med molekylär neurobiologi
Identifikatorer
URN: urn:nbn:se:su:diva-45995ISBN: 0-9715560-5-9 (tryckt)OAI: oai:DiVA.org:su-45995DiVA, id: diva2:370824
Konferanse
31st EPS conference, Sept 5-9, 2010, Copenhagen, Denmark
Tilgjengelig fra: 2013-01-07 Laget: 2010-11-17 Sist oppdatert: 2018-01-12bibliografisk kontrollert

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