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Describing Compton scattering and two-quanta positron annihilation based on Compton profiles: two models suited for the Monte Carlo method
Stockholms universitet, Naturvetenskapliga fakulteten, Fysikum.
2012 (Engelska)Ingår i: Journal of Instrumentation, ISSN 1748-0221, E-ISSN 1748-0221, Vol. 7, s. P07018-Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

An accurate description of the basic physics processes of Compton scattering and positron annihilation in matter requires the consideration of atomic shell structure effects and, in specific, the momentum distributions of the atomic electrons. Two algorithms which model Compton scattering and two-quanta positron annihilation at rest accounting for shell structure effects are proposed. Two-quanta positron annihilation is a physics process which is of particular importance for applications such as positron emission tomography (PET). Both models use a detailed description of the processes which incorporate consistently Doppler broadening and binding effects. This together with the relatively low level of complexity of the models makes them particularly suited to be employed by fast sampling methods for Monte Carlo particle transport. Momentum distributions of shell electrons are obtained from parametrized one-electron Compton profiles. For conduction electrons, momentum distributions are derived in the framework of a Fermi gas. The Compton scattering model uses an approach which does not employ any free parameter. In contrast, a few semi-empirical approximations are included for the description of the complex physics of electron-positron annihilation resulting in acollinear photons. Comparisons of the Compton scattering model with simpler approaches illustrate the detailed accounting for shell structure effects. A satisfactory agreement is found for comparisons of both newly-developed models with experimental data.

Ort, förlag, år, upplaga, sidor
2012. Vol. 7, s. P07018-
Nyckelord [en]
Interaction of radiation with matter; Detector modelling and simulations I (interaction of radiation with matter, interaction of photons with matter, interaction of hadrons with matter, etc); Gamma camera, SPECT, PET PET/CT, coronary CT angiography (CTA)
Nationell ämneskategori
Fysik
Forskningsämne
medicinsk strålningsfysik
Identifikatorer
URN: urn:nbn:se:su:diva-81152DOI: 10.1088/1748-0221/7/07/P07018ISI: 000307076500005OAI: oai:DiVA.org:su-81152DiVA, id: diva2:560040
Tillgänglig från: 2012-10-11 Skapad: 2012-10-11 Senast uppdaterad: 2017-12-07Bibliografiskt granskad
Ingår i avhandling
1. Monte Carlo particle transport codes for ion beam therapy treatment planning: Validation, development and applications
Öppna denna publikation i ny flik eller fönster >>Monte Carlo particle transport codes for ion beam therapy treatment planning: Validation, development and applications
2012 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

External radiotherapy with proton and ion beams needs accurate tools for the dosimetric characterization of treatment fields. Monte Carlo (MC) particle transport codes, such as FLUKA and GEANT4, can be a valuable method to increase accuracy of dose calculations and to support various aspects of ion beam therapy (IBT), such as treatment planning and monitoring. One of the prerequisites for such applications is however that the MC codes are able to model reliably and accurately the relevant physics processes. As a first focus of this thesis work, physics models of MC codes with importance for IBT are developed and validated with experimental data. As a result suitable models and code configurations for applications in IBT are established. The accuracy of FLUKA and GEANT4 in describing nuclear fragmentation processes and the production of secondary charged nuclear fragments is investigated for carbon ion therapy. As a complementary approach to evaluate the capability of FLUKA to describe the characteristics of mixed radiation fields created by ion beams, simulated microdosimetric quantities are compared with experimental data. The correct description of microdosimetric quantities is also important when they are used to predict values of relative biological effectiveness (RBE). Furthermore, two models describing Compton scattering and the acollinearity of two-quanta positron annihilation at rest in media were developed, validated and integrated in FLUKA. The detailed description of these processes is important for an accurate simulation of positron emission tomography (PET) and prompt-γ imaging. Both techniques are candidates to be used in clinical routine to monitor dose administration during cancer treatments with IBT. The second objective of this thesis is to contribute to the development of a MC-based treatment planning tool for protons and ions with atomic number Z ≤ 8 using FLUKA. In contrast to previous clinical FLUKA-based MC implementations for IBT which only re-calculate a given treatment plan, the developed prototype features inverse optimization of absorbed dose and RBE-weighted dose for single fields and simultaneous multiple-field optimization for realistic treatment conditions. In a study using this newly-developed tool, the robustness of IBT treatment fields to uncertainties in the prediction of RBE values is investigated, while comparing different optimization strategies.

Ort, förlag, år, upplaga, sidor
Stockholm: Department of Physics, Stockholm University, 2012. s. 86
Nyckelord
Monte Carlo, ion beam therapy, treatment planning, cancer therapy, microdosimetry
Nationell ämneskategori
Fysik
Forskningsämne
medicinsk strålningsfysik
Identifikatorer
urn:nbn:se:su:diva-81111 (URN)978-91-7447-551-7 (ISBN)
Disputation
2012-11-29, föreläsningssalen, Radiumhemmet, Karolinska universitetssjukhuset, Solna, 09:00 (Engelska)
Opponent
Handledare
Forskningsfinansiär
EU, FP7, Sjunde ramprogrammet, PITN-GA-2008-215840-PARTNEREU, FP7, Sjunde ramprogrammet, ENVISION FP7 Grant Agreement N. 241851
Anmärkning

At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 5: Submitted. Paper 6: Manuscript.

Tillgänglig från: 2012-11-07 Skapad: 2012-10-10 Senast uppdaterad: 2013-04-08Bibliografiskt granskad

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