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Novel Galanin Receptor Subtype Specific Ligand in Depression Like Behavior
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för neurokemi. University of Tartu, Estonia.
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för neurokemi.
Vise andre og tillknytning
2013 (engelsk)Inngår i: Neurochemical Research, ISSN 0364-3190, E-ISSN 1573-6903, Vol. 38, nr 2, s. 398-404Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Neuropeptide galanin and its three receptors, galanin receptor type 1-galanin receptor type 3, are known to be involved in the regulation of numerous psychological processes, including depression. Studies have suggested that stimulation of galanin receptor type 2 (GalR2) leads to attenuation of the depression-like behavior in animals. However, due to the lack of highly selective galanin subtype specific ligands the involvement of different receptors in depression-like behavior is yet not fully known. In the present study we introduce a novel GalR2 selective agonist and demonstrate its ability to produce actions consistent with theorized GalR2 functions and analogous to that of the anti-depressant, imipramine.

sted, utgiver, år, opplag, sider
2013. Vol. 38, nr 2, s. 398-404
Emneord [en]
Galanin, Galaninreceptor type 2, Depression, Agonist, GPCR, Neuropeptide
HSV kategori
Forskningsprogram
neurokemi med molekylär neurobiologi
Identifikatorer
URN: urn:nbn:se:su:diva-84943DOI: 10.1007/s11064-012-0933-8ISI: 000313520400018PubMedID: 23192661OAI: oai:DiVA.org:su-84943DiVA, id: diva2:582060
Forskningsfinansiär
Swedish Research CouncilKnut and Alice Wallenberg FoundationTilgjengelig fra: 2013-01-03 Laget: 2013-01-03 Sist oppdatert: 2018-01-11bibliografisk kontrollert

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