Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Separation of chiral colloidal particles in a helical flow field
Stockholms universitet, Nordiska institutet för teoretisk fysik (Nordita).
2013 (engelsk)Inngår i: Soft Matter, ISSN 1744-683X, E-ISSN 1744-6848, Vol. 9, nr 8, s. 2525-2530Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Stereoisomeric molecules with opposite chirality, so-called enantiomers, often vary regarding their sensory, pharmacological and toxicological properties. Such enantiomer specific effects play a central role in the development, testing and evaluation of drugs, pesticides and food related products. Accordingly, efficient techniques for separation of chiral mixtures into enantiopure compounds are of enormous practical relevance. Most current enantiomer separation methods are based on enantioselective interactions with an auxiliary substance which has to be developed and optimized for different chiral molecules in an elaborate and costly process. Here, we experimentally demonstrate the separation of micron-sized chiral particles in a helical fluid flow which is created inside a microfluidic device patterned with slanted grooves. We observe that the retention time of particles in a helical flow field strongly depends on their chirality which leads to an effective chiral separation within the channel. Our experimental results are confirmed by numerical calculations which demonstrate how the coupling of rotational and translational degrees of freedom leads to differences in the trajectories of particles with opposite chirality. Since our separation mechanism does not rely on material specific interactions, this offers considerable advantages over existing methods. We expect that our approach can be also applied at nanometre length scales by using channels with smaller diameters and with an optimized geometry.

sted, utgiver, år, opplag, sider
2013. Vol. 9, nr 8, s. 2525-2530
HSV kategori
Identifikatorer
URN: urn:nbn:se:su:diva-88324DOI: 10.1039/c2sm27441hISI: 000314268200023OAI: oai:DiVA.org:su-88324DiVA, id: diva2:611834
Merknad

AuthorCount:3;

Tilgjengelig fra: 2013-03-19 Laget: 2013-03-12 Sist oppdatert: 2017-12-06bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekst

Søk i DiVA

Av forfatter/redaktør
Eichhorn, Ralf
Av organisasjonen
I samme tidsskrift
Soft Matter

Søk utenfor DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 109 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf