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ERR gamma Enhances UCP1 Expression and Fatty Acid Oxidation in Brown Adipocytes
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2013 (Engelska)Ingår i: Obesity, ISSN 1930-7381, E-ISSN 1930-739X, Vol. 21, nr 3, s. 516-524Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective: Estrogen-related receptors (ERRs) are important regulators of energy metabolism. Here we investigated the hypothesis that ERR gamma impacts on differentiation and function of brown adipocytes. Design and Methods: We characterize the expression of ERR gamma in adipose tissues and cell models and investigate the effects of modulating ERR? activity on UCP1 gene expression and metabolic features of brown and white adipocytes. Results: ERR gamma was preferentially expressed in brown compared to white fat depots, and ERR gamma was induced during cold-induced browning of subcutaneous white adipose tissue and brown adipogenesis. Overexpression of ERR gamma positively regulated uncoupling protein 1 (UCP1) expression levels during brown adipogenesis. This ERR gamma-induced augmentation of UCP1 expression was independent of the presence of peroxisome proliferator-activated receptor coactivator-1 (PGC-1 alpha) but was associated with increased rates of fatty acid oxidation in adrenergically stimulated cells. ERR? did not influence mitochondrial biogenesis, and its reduced expression in white adipocytes could not explain their low expression level of UCP1. Conclusions: Through its augmenting effect on expression of UCP1, ERR gamma may physiologically be involved in increasing the potential for energy expenditure in brown adipocytes, a function that is becoming of therapeutic interest.

Ort, förlag, år, upplaga, sidor
2013. Vol. 21, nr 3, s. 516-524
Nationell ämneskategori
Endokrinologi och diabetes Näringslära
Identifikatorer
URN: urn:nbn:se:su:diva-92929DOI: 10.1002/oby.20067ISI: 000322087600039OAI: oai:DiVA.org:su-92929DiVA, id: diva2:644136
Forskningsfinansiär
EU, FP7, Sjunde ramprogrammet, HEALTH-F2-2011-278373Vetenskapsrådet
Anmärkning

AuthorCount:11;

Tillgänglig från: 2013-08-29 Skapad: 2013-08-26 Senast uppdaterad: 2022-02-24Bibliografiskt granskad

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Petrovic, NatasaNedergaard, Jan

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Petrovic, NatasaNedergaard, Jan
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Institutionen för molekylär biovetenskap, Wenner-Grens institut
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Obesity
Endokrinologi och diabetesNäringslära

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