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The role of NADPH oxidase (NOX) enzymes in neurodegenerative disease
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för neurokemi.ORCID-id: 0000-0001-9064-5432
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för neurokemi.ORCID-id: 0000-0001-9834-4554
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för neurokemi.ORCID-id: 0000-0002-8630-2127
2013 (engelsk)Inngår i: Frontiers in Biology, ISSN 1674-7992, Vol. 8, nr 2, s. 175-188Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Recently, mounting evidence implicating reactive oxygen species (ROS) generated by NADPH oxidase(NOX) enzymes in the pathogenesis of several neurodegenerative diseases including Amyotrophic lateral sclerosis(ALS), Alzheimer’s (AD), Parkinson’s (PD) and polyglutamine disease, have arisen. NOX enzymes are transmembraneproteins and generate reactive oxygen species by transporting electrons across lipid membranes. Under normal healthyconditions, low levels of ROS produced by NOX enzymes have been shown to play a role in neuronal differentiation andsynaptic plasticity. However, in chronic neurodegenerative diseases over-activation of NOX in neurons, as well as inastrocytes and microglia, has been linked to pathogenic processes such as oxidative stress, exitotoxicity andneuroinflammation. In this review, we summarize the current knowledge about NOX functions in the healthy centralnervous system and especially the role of NOX enzymes in neurodegenerative disease processes.

sted, utgiver, år, opplag, sider
2013. Vol. 8, nr 2, s. 175-188
HSV kategori
Forskningsprogram
neurokemi med molekylär neurobiologi
Identifikatorer
URN: urn:nbn:se:su:diva-108884DOI: 10.1007/s11515-012-1250-yOAI: oai:DiVA.org:su-108884DiVA, id: diva2:761300
Forskningsfinansiär
Swedish Research CouncilTilgjengelig fra: 2014-11-06 Laget: 2014-11-06 Sist oppdatert: 2015-08-27bibliografisk kontrollert

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