Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Palladium-Catalyzed Synthesis of 2,3-Disubstituted Benzofurans: An Approach Towards the Synthesis of Deuterium Labeled Compounds
Stockholm University, Faculty of Science, Department of Organic Chemistry.ORCID iD: 0000-0002-9349-7137
2015 (English)In: Advanced Synthesis and Catalysis, ISSN 1615-4150, E-ISSN 1615-4169, Vol. 357, no 10, p. 2331-2338Article in journal (Refereed) Published
Abstract [en]

Palladium-catalyzed oxidative annulations between phenols and alkenylcarboxylic acids produced a library of benzofuran compounds. Depending on the nature of the substitution of the phenol precursor, either 2,3-dialkylbenzofurans or 2-alkyl-3-methylene-2,3-dihydrobenzofurans can be synthesized with excellent regioselectivity. Reactions between conjugated 5-phenylpenta-2,4-dienoic acids and phenol gave 3-alkylidenedihydrobenzofuran alkaloid motifs while biologically active 7-arylbenzofuran derivatives were prepared by starting from 2-phenylphenols. More interestingly, selective incorporation of deuterium from D2O has been discovered, which offers an attractive one-step method to access deuterated compounds.

Place, publisher, year, edition, pages
2015. Vol. 357, no 10, p. 2331-2338
Keywords [en]
benzofurans, C-H activation, deuterium, palladium, synthetic methods
National Category
Organic Chemistry
Identifiers
URN: urn:nbn:se:su:diva-119560DOI: 10.1002/adsc.201500308ISI: 000358208000023OAI: oai:DiVA.org:su-119560DiVA, id: diva2:846794
Funder
Swedish Research CouncilAvailable from: 2015-08-18 Created: 2015-08-17 Last updated: 2022-02-23Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full text

Authority records

Szabó, Kálmán J.

Search in DiVA

By author/editor
Szabó, Kálmán J.
By organisation
Department of Organic Chemistry
In the same journal
Advanced Synthesis and Catalysis
Organic Chemistry

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 722 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf