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Leptin Raises Defended Body Temperature without Activating Thermogenesis
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för molekylär biovetenskap, Wenner-Grens institut. University Medical Center Hamburg-Eppendorf, Germany.
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för molekylär biovetenskap, Wenner-Grens institut.
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för molekylär biovetenskap, Wenner-Grens institut.ORCID-id: 0000-0001-8044-5410
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Rekke forfattare: 82016 (engelsk)Inngår i: Cell Reports, E-ISSN 2211-1247, Vol. 14, nr 7, s. 1621-1631Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Leptin has been believed to exert its weight-reducing action not only by inducing hypophagia but also by increasing energy expenditure/thermogenesis. Leptin-deficient ob/ob mice have correspondingly been thought to be thermogenically limited and to show hypothermia, mainly due to atrophied brown adipose tissue (BAT). In contrast to these established views, we found that BAT is fully functional and that leptin treatment did not increase thermogenesis in wildtype or in ob/ob mice. Rather, ob/ob mice showed a decreased but defended body temperature (i. e., were anapyrexic, not hypothermic) that was normalized to wild-type levels after leptin treatment. This was not accompanied by increased energy expenditure or BAT recruitment but, instead, was mediated by decreased tail heat loss. The weight-reducing hypophagic effects of leptin are, therefore, not augmented through a thermogenic effect of leptin; leptin is, however, pyrexic, i. e., it alters centrally regulated thresholds of thermoregulatory mechanisms, in parallel to effects of other cytokines.

sted, utgiver, år, opplag, sider
2016. Vol. 14, nr 7, s. 1621-1631
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URN: urn:nbn:se:su:diva-128471DOI: 10.1016/j.celrep.2016.01.041ISI: 000370970200007PubMedID: 26876182OAI: oai:DiVA.org:su-128471DiVA, id: diva2:915427
Tilgjengelig fra: 2016-03-30 Laget: 2016-03-29 Sist oppdatert: 2024-01-17bibliografisk kontrollert

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Fischer, Alexander W.Abreu-Vieira, Gustavode Jong, Jasper M. A.Petrovic, NatasaCannon, BarbaraNedergaard, Jan

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