Change search
ReferencesLink to record
Permanent link

Direct link
Combining escitalopram and cognitive–behavioural therapy for social anxiety disorder: randomised controlled fMRI trial
Uppsala University.
Uppsala University.
Uppsala University.
Uppsala University.
Show others and affiliations
2016 (English)In: British Journal of Psychiatry, ISSN 0007-1250, E-ISSN 1472-1465, Vol. 209, no 3, 229-235 p.Article in journal (Refereed) Published
Abstract [en]


Selective serotonin reuptake inhibitors (SSRIs) and cognitive–behavioural therapy (CBT) are often used concomitantly to treat social anxiety disorder (SAD), but few studies have examined the effect of this combination.


To evaluate whether adding escitalopram to internet-delivered CBT (ICBT) improves clinical outcome and alters brain reactivity and connectivity in SAD.


Double-blind, randomised, placebo-controlled neuroimaging trial of ICBT combined either with escitalopram (n = 24) or placebo (n = 24), including a 15-month clinical follow-up (trial registration: ISRCTN24929928).


Escitalopram+ICBT, relative to placebo+ICBT, resulted in significantly more clinical responders, larger reductions in anticipatory speech state anxiety at post-treatment and larger reductions in social anxiety symptom severity at 15-month follow-up and at a trend-level (P = 0.09) at post-treatment. Right amygdala reactivity to emotional faces also decreased more in the escitalopram+ICBT combination relative to placebo+ICBT, and in treatment responders relative to non-responders.


Adding escitalopram improves the outcome of ICBT for SAD and decreased amygdala reactivity is important for anxiolytic treatment response.

Place, publisher, year, edition, pages
2016. Vol. 209, no 3, 229-235 p.
Keyword [en]
escitalopram, cognitive-behavioural therapy, CBT, ICBT, social anxiety disorder, SAD, fMRI
National Category
Research subject
URN: urn:nbn:se:su:diva-134611DOI: 10.1192/bjp.bp.115.175794PubMedID: 27340112OAI: diva2:1034620
Available from: 2016-10-12 Created: 2016-10-12 Last updated: 2016-10-13

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Carlbring, Per
By organisation
Clinical psychology
In the same journal
British Journal of Psychiatry

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

ReferencesLink to record
Permanent link

Direct link