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Mild Synthesis of Sterically Congested Alkyl Aryl Ethers
Stockholm University, Faculty of Science, Department of Organic Chemistry.
Stockholm University, Faculty of Science, Department of Organic Chemistry.
Stockholm University, Faculty of Science, Department of Organic Chemistry.
Number of Authors: 3
2016 (English)In: Organic Letters, ISSN 1523-7060, E-ISSN 1523-7052, Vol. 18, no 17, 4234-4237 p.Article in journal (Refereed) Published
Abstract [en]

An efficient and transition-metal-free method is presented to access tertiary alkyl aryl ethers by arylation of tertiary alcohols with ortho-substituted diaryliodonium salts. The scope covers cyclic and acyclic aliphatic, benzylic, allylic, and propargylic tertiary alcohols as well as primary and secondary fluorinated alcohols. The methodology gives access to alkyl aryl ethers of previously unprecedented steric congestion. Furthermore, the versatility of the developed procedure was demonstrated by arylation of the pro-drug mestranol.

Place, publisher, year, edition, pages
2016. Vol. 18, no 17, 4234-4237 p.
National Category
Organic Chemistry
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URN: urn:nbn:se:su:diva-135023DOI: 10.1021/acs.orglett.6b01975ISI: 000382711200022PubMedID: 27586361OAI: oai:DiVA.org:su-135023DiVA: diva2:1045769
Available from: 2016-11-10 Created: 2016-10-31 Last updated: 2016-11-10Bibliographically approved

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Lindstedt, ErikStridfeldt, ElinOlofsson, Berit
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