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Diurnal Variation of Circulating Interleukin-6 in Humans: A Meta-Analysis
Stockholm University, Faculty of Social Sciences, Stress Research Institute. Karolinska Institutet, Sweden.
Stockholm University, Faculty of Social Sciences, Stress Research Institute. Karolinska Institutet, Sweden.
Stockholm University, Faculty of Social Sciences, Stress Research Institute. Karolinska Institutet, Sweden.
Stockholm University, Faculty of Social Sciences, Stress Research Institute. Karolinska Institutet, Sweden.
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2016 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, no 11, e0165799Article in journal (Refereed) Published
Abstract [en]

The pleiotropic cytokine interleukin-6 (IL-6) has been proposed to contribute to circadian regulation of sleepiness by increasing in the blood at night. Earlier studies have reported diurnal variation of IL-6, but phase estimates are conflicting. We have therefore performed a meta-analysis on the diurnal variation of circulating IL-6. Studies were included if they reported IL-6 in plasma or serum recorded at least twice within 24 hours in the same individual. A systematic search resulted in the inclusion of 43 studies with 56 datasets, for a total of 1100 participants. Individual participant data were available from 4 datasets with a total of 56 participants. Mixed-effects meta-regression modelling confirmed that IL-6 varied across the day, the most conspicuous effect being a trough in the morning. These results stand in contrast to earlier findings of a peak in the evening or night, and suggest that diurnal variation should be taken into account in order to avoid confounding by time of day in studies of IL-6 in plasma or serum.

Place, publisher, year, edition, pages
2016. Vol. 11, no 11, e0165799
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Environmental Health and Occupational Health Clinical Laboratory Medicine
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URN: urn:nbn:se:su:diva-135822DOI: 10.1371/journal.pone.0165799ISI: 000387725000035PubMedID: 27832117Local ID: P-3377OAI: oai:DiVA.org:su-135822DiVA: diva2:1049342
Available from: 2016-11-24 Created: 2016-11-24 Last updated: 2016-12-12Bibliographically approved

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Nilsonne, GustavLekander, MatsÅkerstedt, TorbjörnAxelsson, JohnIngre, Michael
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