Fluorinative ring-opening of cyclopropanes by hypervalent iodine reagents. An efficient method for 1,3-oxyfluorination and 1,3-difluorination
2016 (English)In: Chemical Sience, ISSN 2041-6539Article in journal (Refereed) Epub ahead of print
A new method is presented for 1,3-difluorination and 1,3-oxyfluorination reactions. The process is based on iodonium mediated opening of 1,1-disubstituted cyclopropanes. The reaction proceeds with high chemo- and regioselectivity under mild reaction conditions typically at room temperature in a couple of hours. The reaction probably occurs via electrophilic ring-opening of cyclopropanes.
Place, publisher, year, edition, pages
Research subject Organic Chemistry
IdentifiersURN: urn:nbn:se:su:diva-136206DOI: 10.1039/c6sc03471cOAI: oai:DiVA.org:su-136206DiVA: diva2:1051127