Highly Efficient Cascade Reaction for Selective Formation of Spirocyclobutenes from Dienallenes via Palladium-Catalyzed Oxidative Double Carbocyclization-Carbonylation-Alkynylation
Number of Authors: 4
2016 (English)In: Journal of the American Chemical Society, ISSN 0002-7863, E-ISSN 1520-5126, Vol. 138, no 42, 13846-13849 p.Article in journal (Refereed) Published
A highly selective cascade reaction that allows the direct transformation of dienallenes to spirocyclobutenes (spiro[3.4]octenes) as single diastereoisomers has been developed. The reaction involves formation of overall four C-C bonds and proceeds-via a palladium-catalyzed oxidative transformation with insertion of olefin, olefin, and carbon monoxide. Under slightly different reaction conditions, an additional CO insertion takes place to give spiro[4.4]nonenes with formation of overall five C-C bonds.
Place, publisher, year, edition, pages
2016. Vol. 138, no 42, 13846-13849 p.
IdentifiersURN: urn:nbn:se:su:diva-136928DOI: 10.1021/jacs.6b09240ISI: 000386540500021OAI: oai:DiVA.org:su-136928DiVA: diva2:1061670