Perspectives in radiation biophysics: From radiation track structure simulation to mechanistic models of DNA damage and repair
Number of Authors: 5
2016 (English)In: Radiation Physics and Chemistry, ISSN 0969-806X, E-ISSN 1879-0895, Vol. 128, 3-10 p.Article in journal (Refereed) Published
In radiation targeted therapy and genetic risk estimation of low dose radiation protection there is a crucial need for full description of DNA damage response and repair (DDR) leading to cell death and cell mutation. We propose such a description can be arrived through realistic track-structure simulations together with mechanistic mathematical formulation of DDR and the availability of experimental data for testing the proof of principle. In this paper we review briefly first the state of the art in DNA damage and repair, and then the recent advances in the physics of track structure which represents an essential tool in radiation biophysics.
Place, publisher, year, edition, pages
2016. Vol. 128, 3-10 p.
DNA damage, DNA repair, Track structure, Cross sections, Monte Carlo
Chemical Sciences Mechanical Engineering Physical Sciences
IdentifiersURN: urn:nbn:se:su:diva-136041DOI: 10.1016/j.radphyschem.2016.05.005ISI: 000385325400002OAI: oai:DiVA.org:su-136041DiVA: diva2:1061814