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Nanocellulose-Based Interpenetrating Polymer Network (IPN) Hydrogels for Cartilage Applications
Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK). Luleå University of Technology, Sweden.
Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK). Luleå University of Technology, Sweden.
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Number of Authors: 52016 (English)In: Biomacromolecules, ISSN 1525-7797, E-ISSN 1526-4602, Vol. 17, no 11, p. 3714-3723Article in journal (Refereed) Published
Abstract [en]

Double cross-linked interpenetrating polymer network (IPN) hydrogels of sodium alginate and gelatin (SA/G) reinforced with 50 wt % cellulose nanocrystals (CNC) have been prepared via the freeze-drying process. The IPNs were designed to incorporate CNC with carboxyl surface groups as a part of the network contribute to the structural integrity and mechanical stability of the hydrogel. Structural morphology studies of the hydrogels showed a three-dimensional (3D) network of interconnected pores with diameters in the range of 10-192 mu m and hierarchical pores with a nanostructured pore wall roughness, which has potential benefits for cell adhesion. Significant improvements in the tensile strength and strain were achieved in 98% RH at 37 degrees C for CNC cross-linked IPNs. The high porosity of the scaffolds (>93%), high phosphate buffered saline (PBS) uptake, and cytocompatibility toward mesenchymal stem cells (MSCs) are confirmed and considered beneficial for use as a substitute for cartilage.

Place, publisher, year, edition, pages
2016. Vol. 17, no 11, p. 3714-3723
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Chemical Sciences
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URN: urn:nbn:se:su:diva-137752DOI: 10.1021/acs.biomac.6b01243ISI: 000388155400027OAI: oai:DiVA.org:su-137752DiVA, id: diva2:1064860
Available from: 2017-01-13 Created: 2017-01-10 Last updated: 2017-11-29Bibliographically approved

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Naseri, NargesMathew, Aji P.
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