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Causes of Death According to Death Certificates in Individuals with Dementia: A Cohort from the Swedish Dementia Registry
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI). Jönköping University, Sweden.
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI).
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Number of Authors: 6
2016 (English)In: Journal of The American Geriatrics Society, ISSN 0002-8614, E-ISSN 1532-5415, Vol. 64, no 11, E137-E142 p.Article in journal (Refereed) Published
Abstract [en]

Objectives

The causes of death in dementia are not established, particularly in rarer dementias. The aim of this study is to calculate risk of death from specific causes for a broader spectrum of dementia diagnoses.

Design

Cohort study.

Setting

Swedish Dementia Registry (SveDem), 2007–2012.

Participants

Individuals with incident dementia registered in SveDem (N = 28,609); median follow-up 741 days. Observed deaths were 5,368 (19%).

Measurements

Information on number of deaths and causes of mortality was obtained from death certificates. Odds ratios for the presence of dementia on death certificates were calculated. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox hazards regression for cause-specific mortality, using Alzheimer's dementia (AD) as reference. Hazard ratios for death for each specific cause of death were compared with hazard ratios of death from all causes (P-values from t-tests).

Results

The most frequent underlying cause of death in this cohort was cardiovascular (37%), followed by dementia (30%). Dementia and cardiovascular causes appeared as main or contributory causes on 63% of certificates, followed by respiratory (26%). Dementia was mentioned less in vascular dementia (VaD; 57%). Compared to AD, cardiovascular mortality was higher in individuals with VaD than in those with AD (HR = 1.82, 95% CI = 1.64–2.02). Respiratory death was higher in individuals with Lewy body dementia (LBD, including Parkinson's disease dementia and dementia with Lewy bodies, HR = 2.16, 95% CI = 1.71–2.71), and the risk of respiratory death was higher than expected from the risk for all-cause mortality. Participants with frontotemporal dementia were more likely to die from external causes of death than those with AD (HR = 2.86, 95% CI = 1.53–5.32).

Conclusion

Dementia is underreported on death certificates as main and contributory causes. Individuals with LBD had a higher risk of respiratory death than those with AD.

Place, publisher, year, edition, pages
2016. Vol. 64, no 11, E137-E142 p.
Keyword [en]
causes of death, dementia, death certificate, Alzheimer's, Lewy body dementia, respiratory death, survival analyses
National Category
Gerontology, specializing in Medical and Health Sciences Geriatrics
Identifiers
URN: urn:nbn:se:su:diva-137740DOI: 10.1111/jgs.14421ISI: 000388335600003PubMedID: 27801938OAI: oai:DiVA.org:su-137740DiVA: diva2:1064911
Available from: 2017-01-13 Created: 2017-01-10 Last updated: 2017-01-13Bibliographically approved

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Gerontology, specializing in Medical and Health SciencesGeriatrics

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