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Loss of Olfactory Function Predicts Mortality Irrespective of Dementia Conversion: 10-year follow-up of an age-varied sample
Stockholm University, Faculty of Social Sciences, Department of Psychology, Perception and psychophysics.
Stockholm University, Faculty of Social Sciences, Department of Psychology, Perception and psychophysics.
Stockholm University, Faculty of Social Sciences, Department of Psychology, Perception and psychophysics.
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2016 (English)In: 17th International Symposium on Olfaction and Taste (ISOT2016), Yokohama, Japan, June 5-9, 2016. Chemical Senses, 41(9), Oxford University Press, 2016, Vol. 41(9), E216- p.Conference paper, Poster (Refereed)
Abstract [en]

The objective of this study was to examine the association between performance in odor identification and future mortality in a community cohort of adults aged between 40 and 90 years. We assessed olfactory performance with a 13-item-version of the Scandinavian Odor Identification Test (SOIT). The results showed that during follow-up (mean=9.4 years, standard deviation=2.23), 411 of 1774 (23.2%) participants died. In a Cox model, the association between higher SOIT score and mortality was highly significant (hazard ratio [HR]=0.74, per point interval, 95% confidence interval [CI]=0.71–0.77, p<0.001). The effect was attenuated, but remained significant after controlling for age, sex, education, and health and cognitive variables that were also associated with an increased risk of mortality (HR=0.92, 95% CI=0.87–0.97, p=0.001). Controlling for dementia conversion prior to death did not attenuate the association between SOIT score and mortality (HR=0.92, 95% CI=0.87–0.97, p=0.001). Similar results were obtained for olfactory sensitivity as assessed by self-report. Overall, the present findings show that poor odor identification performance is associated with an increased likelihood of future mortality in middle-aged and older adults, after controlling for social, cognitive, and medical risk factors. Most importantly, controlling for the development of dementia did not attenuate the association between odor identification and mortality, suggesting that olfactory decline might mark deteriorating health also irrespective of dementia.

Place, publisher, year, edition, pages
Oxford University Press, 2016. Vol. 41(9), E216- p.
Keyword [en]
olfactory function, mortality, dementia, follow-up
National Category
Psychology
Research subject
Psychology
Identifiers
URN: urn:nbn:se:su:diva-137925DOI: 10.1093/chemse/bjw091OAI: oai:DiVA.org:su-137925DiVA: diva2:1065156
Conference
17th International Symposium on Olfaction and Taste (ISOT2016), Yokohama, Japan, June 5-9, 2016
Available from: 2017-01-13 Created: 2017-01-13 Last updated: 2017-01-13

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Larsson, MariaEkström, IngridSjölund, SaraNilsson, Lars-GöranOlofsson, Jonas K.
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