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Cardioprotection and lifespan extension by the natural polyamine spermidine
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Number of Authors: 59
2016 (English)In: Nature Medicine, ISSN 1078-8956, E-ISSN 1546-170X, Vol. 22, no 12, 1428-1438 p.Article in journal (Refereed) Published
Abstract [en]

Aging is associated with an increased risk of cardiovascular disease and death. Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. Spermidine feeding enhanced cardiac autophagy, mitophagy and mitochondrial respiration, and it also improved the mechano-elastical properties of cardiomyocytes in vivo, coinciding with increased titin phosphorylation and suppressed subclinical inflammation. Spermidine feeding failed to provide cardioprotection in mice that lack the autophagy-related protein Atg5 in cardiomyocytes. In Dahl salt-sensitive rats that were fed a high-salt diet, a model for hypertension-induced congestive heart failure, spermidine feeding reduced systemic blood pressure, increased titin phosphorylation and prevented cardiac hypertrophy and a decline in diastolic function, thus delaying the progression to heart failure. In humans, high levels of dietary spermidine, as assessed from food questionnaires, correlated with reduced blood pressure and a lower incidence of cardiovascular disease. Our results suggest a new and feasible strategy for protection against cardiovascular disease.

Place, publisher, year, edition, pages
2016. Vol. 22, no 12, 1428-1438 p.
National Category
Biological Sciences Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:su:diva-137601DOI: 10.1038/nm.4222ISI: 000389549000020OAI: oai:DiVA.org:su-137601DiVA: diva2:1065740
Available from: 2017-01-16 Created: 2017-01-09 Last updated: 2017-01-16Bibliographically approved

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Büttner, Sabrina
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Department of Molecular Biosciences, The Wenner-Gren Institute
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