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Uncertainty of fast biological radiation dose assessment for emergency response scenarios
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Number of Authors: 22
2017 (English)In: International Journal of Radiation Biology, ISSN 0955-3002, E-ISSN 1362-3095, Vol. 93, no 1, 127-135 p.Article in journal (Refereed) Published
Abstract [en]

Purpose: Reliable dose estimation is an important factor in appropriate dosimetric triage categorization of exposed individuals to support radiation emergency response. Materials and methods: Following work done under the EU FP7 MULTIBIODOSE and RENEB projects, formal methods for defining uncertainties on biological dose estimates are compared using simulated and real data from recent exercises. Results: The results demonstrate that a Bayesian method of uncertainty assessment is the most appropriate, even in the absence of detailed prior information. The relative accuracy and relevance of techniques for calculating uncertainty and combining assay results to produce single dose and uncertainty estimates is further discussed. Conclusions: Finally, it is demonstrated that whatever uncertainty estimation method is employed, ignoring the uncertainty on fast dose assessments can have an important impact on rapid biodosimetric categorization.

Place, publisher, year, edition, pages
2017. Vol. 93, no 1, 127-135 p.
Keyword [en]
Biodosimetry, retrospective dosimetry, radiation, triage screening, uncertainty
National Category
Biological Sciences Mechanical Engineering Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:su:diva-140238DOI: 10.1080/09553002.2016.1227106ISI: 000392891400016PubMedID: 27572921OAI: oai:DiVA.org:su-140238DiVA: diva2:1078794
Available from: 2017-03-06 Created: 2017-03-06 Last updated: 2017-03-06Bibliographically approved

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Brzozowska, Beata
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Department of Molecular Biosciences, The Wenner-Gren Institute
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