Web based scoring is useful for validation and harmonisation of scoring criteria within RENEB
Number of Authors: 28
2017 (English)In: International Journal of Radiation Biology, ISSN 0955-3002, E-ISSN 1362-3095, Vol. 93, no 1, 110-117 p.Article in journal (Refereed) Published
Purpose: To establish a training data set of digital images and to investigate the scoring criteria and dose assessment of the dicentric assay within the European network of biodosimetry (RENEB), a web based scoring inter-comparison was undertaken by 17 RENEB partners. Materials and methods: Two sets of 50 high resolution images were uploaded onto the RENEB web site. One set included metaphases after a moderate exposure (1.3 Gy) and the other set consisted of metaphases after a high dose exposure (3.5 Gy). The laboratories used their own calibration curves for estimating doses based on observed aberration frequencies. Results: The dose estimations and 95% confidence limits were compared to the actual doses and the corresponding z-values were satisfactory for the majority; only the dose estimations from two laboratories were too low or too high. The coefficients of variation were 17.6% for the moderate and 11.2% for the high dose. Metaphases with controversial results could be identified for training purposes. Conclusions: Overall, the web based scoring of the two galleries by the 17 laboratories produced very good results. Application of web based scoring for the dicentric assay may therefore be a relevant strategy for an operational biodosimetry assistance network.
Place, publisher, year, edition, pages
2017. Vol. 93, no 1, 110-117 p.
Web based scoring, biological dosimetry, dicentric assay, radiation, biodosimetry network
Biological Sciences Mechanical Engineering Radiology, Nuclear Medicine and Medical Imaging
IdentifiersURN: urn:nbn:se:su:diva-140236DOI: 10.1080/09553002.2016.1206228ISI: 000392891400014PubMedID: 27547893OAI: oai:DiVA.org:su-140236DiVA: diva2:1078807