Targeted DNA sequencing and in situ mutation analysis using mobile phone microscopy
Number of Authors: 12
2017 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 8, 13913Article in journal (Refereed) Published
Molecular diagnostics is typically outsourced to well-equipped centralized laboratories, often far from the patient. We developed molecular assays and portable optical imaging designs that permit on-site diagnostics with a cost-effective mobile-phone-based multimodal microscope. We demonstrate that targeted next-generation DNA sequencing reactions and in situ point mutation detection assays in preserved tumour samples can be imaged and analysed using mobile phone microscopy, achieving a new milestone for tele-medicine technologies.
Place, publisher, year, edition, pages
2017. Vol. 8, 13913
Biochemistry and Molecular Biology
IdentifiersURN: urn:nbn:se:su:diva-140210DOI: 10.1038/ncomms13913ISI: 000391931300001PubMedID: 28094784OAI: oai:DiVA.org:su-140210DiVA: diva2:1079343