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Targeted DNA sequencing and in situ mutation analysis using mobile phone microscopy
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics. Stockholm University, Science for Life Laboratory (SciLifeLab). Uppsala University, Sweden.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics. Stockholm University, Science for Life Laboratory (SciLifeLab).
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Number of Authors: 12
2017 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 8, 13913Article in journal (Refereed) Published
Abstract [en]

Molecular diagnostics is typically outsourced to well-equipped centralized laboratories, often far from the patient. We developed molecular assays and portable optical imaging designs that permit on-site diagnostics with a cost-effective mobile-phone-based multimodal microscope. We demonstrate that targeted next-generation DNA sequencing reactions and in situ point mutation detection assays in preserved tumour samples can be imaged and analysed using mobile phone microscopy, achieving a new milestone for tele-medicine technologies.

Place, publisher, year, edition, pages
2017. Vol. 8, 13913
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Biochemistry and Molecular Biology
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URN: urn:nbn:se:su:diva-140210DOI: 10.1038/ncomms13913ISI: 000391931300001PubMedID: 28094784OAI: oai:DiVA.org:su-140210DiVA: diva2:1079343
Available from: 2017-03-08 Created: 2017-03-08 Last updated: 2017-03-08Bibliographically approved

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Kühnemund, MalteDarai, EvangeliaHernández-Neuta, IvánNilsson, Mats
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