Chemoenzymatic Dynamic Kinetic Resolution of Secondary Alcohols Using an Air- and Moisture-Stable Iron Racemization Catalyst
Number of Authors: 4
2017 (English)In: Chemistry - A European Journal, ISSN 0947-6539, E-ISSN 1521-3765, Vol. 23, no 5, 1048-1051 p.Article in journal (Refereed) Published
Herein, we report on a metalloenzymatic dynamic kinetic resolution of sec-alcohols employing an iron-based racemization catalyst together with a lipase. The iron catalyst was evaluated in racemization and then used in dynamic kinetic resolution of a number of sec-alcohols to give enantiomerically pure products in good to high yields. The iron catalyst is air and moisture stable and is readily accessible.
Place, publisher, year, edition, pages
2017. Vol. 23, no 5, 1048-1051 p.
dynamic kinetic resolution, enzyme catalysis, iron catalysis, racemization, secondary alcohols
IdentifiersURN: urn:nbn:se:su:diva-141286DOI: 10.1002/chem.201605754ISI: 000395753000014PubMedID: 28005307OAI: oai:DiVA.org:su-141286DiVA: diva2:1086882