Mixed brain lesions mediate the association between cardiovascular risk burden and cognitive decline in old age: A population-based study
Number of Authors: 9
2017 (English)In: Alzheimer's & Dementia, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 13, no 3, 247-256 p.Article in journal (Refereed) Published
Introduction: The underlying pathological mechanisms linking cardiovascular burden to cognitive decline remain unclear. Methods: We investigated the associations of the Framingham general cardiovascular risk score (FGCRS), apolipoprotein E (APOE) 64, and brain structure with the Mini-Mental State Examination (MMSE) decline using the 9-year follow-up data from Swedish National Study on Aging and Care in Kungsholmen (n = 2189, age >= 60) and the embedded magnetic resonance imaging (MRI) (n = 448) studies. Volumes of white matter hyperintensities (WMHs), total gray matter, ventricles, and hippo campus were assessed in the MRI sample. Results: A higher FGCRS was associated with faster MMSE decline in young-old people (60-72 years) but not in old-old (>= 78 years). Larger volumes of cerebral WMHs and ventricles and smaller volumes of total gray matter and hippocampus were all associated with accelerated MMSE decline (P <.01); these associations were stronger among APOE epsilon 4 carriers than noncarriers. Simultaneously entering multiple brain lesion markers as mediators in the model substantially attenuated the association between FGCRS and MMSE decline. Discussion: The effect of cardiovascular risk burden on cognitive deterioration in old age is largely mediated by mixed brain lesions.
Place, publisher, year, edition, pages
2017. Vol. 13, no 3, 247-256 p.
Framingham general cardiovascular risk score, Magnetic resonance imaging, Cerebral small-vessel disease, Cognitive decline, Aging, Population study
IdentifiersURN: urn:nbn:se:su:diva-141323DOI: 10.1016/j.jalz.2016.06.2363ISI: 000395968200006PubMedID: 27521789OAI: oai:DiVA.org:su-141323DiVA: diva2:1086968