Palladium-Catalyzed Oxidative Carbocyclization–Borylation of Enallenes to Cyclobutenes
2016 (English)In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 55, no 22, 6520-6524 p.Article in journal (Refereed) Published
A highly efficient palladium-catalyzed oxidative borylation of enallenes was developed for the selective formation of cyclobutene derivatives and fully-substituted alkenylboron compounds. Cyclobutenes are formed as the exclusive products in MeOH in the presence of H2O and Et3N, whereas the use of AcOH leads to alkenylboron compounds. Both reactions showed a broad substrate scope and good tolerance for various functional groups, including carboxylic acid ester, free hydroxy, imide, and alkyl groups. Furthermore, transformations of the borylated products were conducted to show their potential applications.
Place, publisher, year, edition, pages
2016. Vol. 55, no 22, 6520-6524 p.
Research subject Organic Chemistry
IdentifiersURN: urn:nbn:se:su:diva-141525DOI: 10.1002/anie.201601613OAI: oai:DiVA.org:su-141525DiVA: diva2:1087128
FunderEU, European Research Council