Enantioselective Palladium-Catalyzed Carbonylative Carbocyclization of Enallenes via Cross-Dehydrogenative Coupling with Terminal Alkyne: Efficient Construction of a-Chirality of Ketones
2017 (English)In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 56, no 16, 4535-4539 p.Article in journal (Refereed) Published
An enantioselective PdII/Brønsted acid-catalyzed carbonylative carbocyclization of enallenes ending with a cross-dehydrogenative coupling (CDC) with a terminal alkyne was developed. VAPOL phosphoric acid was found as the best co-catalyst among the examined 28 chiral acids, for inducing the enantioselectivity of α-chiral ketones. As a result, a number of chiral cyclopentenones were easily synthesized in good to excellent enantiomeric ratio with good yields.
Place, publisher, year, edition, pages
2017. Vol. 56, no 16, 4535-4539 p.
Research subject Organic Chemistry
IdentifiersURN: urn:nbn:se:su:diva-141526DOI: 10.1002/anie.201612385OAI: oai:DiVA.org:su-141526DiVA: diva2:1087131
FunderEU, European Research Council