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Estradiol and Cognition in the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) Cohort Study
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Number of Authors: 5
2017 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 56, no 2, 453-458 p.Article in journal (Refereed) Published
Abstract [en]

Cardiovascular Risk factors, Aging and Dementia (CAIDE) is a Finnish population-based study. 731 cognitively normal women had self-reported hormone therapy (HT) data in 1998 as: no use, use <= 5 years, and >5 years. Information on type of HT was only available from 1995-1998 (Prescription Register). Cognition was assessed in 1998 and 2005-2008. Longterm (>5 years) HT use, especially use of estradiol alone among women having hysterectomy with bilateral oophorectomy, was associated with better episodic memory in 1998, but not in 2005-2008. Although a strong evidence for protective effect of estradiol on cognition was not observed in our study, improved global cognition among long-term users suggests that long-term postmenopausal HT may be beneficial for some cognitive domains.

Place, publisher, year, edition, pages
2017. Vol. 56, no 2, 453-458 p.
Keyword [en]
Cognition, dementia, estradiol, hormone therapy, menopause
National Category
Neurosciences Neurology
Identifiers
URN: urn:nbn:se:su:diva-141246DOI: 10.3233/JAD-160643ISI: 000395077200004PubMedID: 27983549OAI: oai:DiVA.org:su-141246DiVA: diva2:1088961
Available from: 2017-04-18 Created: 2017-04-18 Last updated: 2017-04-18Bibliographically approved

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