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HieranoiDB: a database of orthologs inferred by Hieranoid
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics. Stockholm University, Science for Life Laboratory (SciLifeLab).
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics. Stockholm University, Science for Life Laboratory (SciLifeLab). FH OÖ - University of Applied Sciences Upper Austria, Austria.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics. Stockholm University, Science for Life Laboratory (SciLifeLab). FH OÖ - University of Applied Sciences Upper Austria, Austria.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics. Stockholm University, Science for Life Laboratory (SciLifeLab).
Number of Authors: 4
2017 (English)In: Nucleic Acids Research, ISSN 0305-1048, E-ISSN 1362-4962, Vol. 45, no D1, D687-D690 p.Article in journal (Refereed) Published
Abstract [en]

HieranoiDB (http://hieranoiDB.sbc.su.se) is a freely available on-line database for hierarchical groups of orthologs inferred by the Hieranoid algorithm. It infers orthologs at each node in a species guide tree with the InParanoid algorithm as it progresses from the leaves to the root. Here we present a database HieranoiDB with a web interface that makes it easy to search and visualize the output of Hieranoid, and to download it in various formats. Searching can be performed using protein description, identifier or sequence. In this first version, orthologs are available for the 66 Quest for Orthologs reference proteomes. The ortholog trees are shown graphically and interactively with marked speciation and duplication nodes that show the inferred evolutionary scenario, and allow for correct extraction of predicted orthologs from the Hieranoid trees.

Place, publisher, year, edition, pages
2017. Vol. 45, no D1, D687-D690 p.
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-141235DOI: 10.1093/nar/gkw923ISI: 000396575500096PubMedID: 27742821OAI: oai:DiVA.org:su-141235DiVA: diva2:1089040
Available from: 2017-04-18 Created: 2017-04-18 Last updated: 2017-04-18Bibliographically approved

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Kaduk, MateuszSonnhammer, Erik L. L.
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